We are developing electroacoustic tomography (EAT), a new imaging modality that leverages electrical energy deposition to stimulate the emission of broadband ultrasound waves. EAT can achieve submillimeter resolution up to 10 centimeters in depth and up to 100 frames per second imaging speed using an ultrasound array system. EAT is a promising label-free and high-resolution method for real-time assessment of deep tissue electroporation during treatment, with a wide range of applications in biotechnology and medicine.
Selected papers:
- Mengxiao Wang, Ali Zarafshani, Pratik Samant, Jack Merrill, Dengwang Li, Liangzhong Xiang. Feasibility of Electroacoustic Tomography: A Simulation Study, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 11/25 (2019).
- Ali Zarafshani, John A. Merrill, Siqi Wang, Mengxiao Wang, Bin Zheng, Liangzhong Xiang. Electroacoustic tomography (EAT): linear scanning with a single element transducer, SPIE Medical Imaging, 10955-38 (2019).
- Ali Zarafshani, Siqi Wang, Jack Merrill, Bin Zheng, Liangzhong Xiang. Electroacoustic tomography system with nanosecond electric pulse excitation source, SPIE Medical Imaging, 10955-49 (2019).
- Ali Zarafshani, Rowzat Faiz, Pratik Samant, Bin Zheng, Liangzhong Xiang. Real time, in situ monitoring of nanoporation using electric field-induced acoustic signal, SPIE BiOS, 10495-25 (2018).
- Ali Zarafshani, Nicklas Dang, Pratik Samant, Rowzat Faiz, Bin Zheng, Liangzhong Xiang. Real time, in situ monitoring of electrotherapy process using electric pulse-induced acoustic tomography (EPAT), SPIE Medical Imaging, 10573-90 (2018).